|
KMID : 0358419970400020321
|
|
Korean Journal of Obstetrics and Gynecology
1997 Volume.40 No. 2 p.321 ~ p.329
|
|
|
The Effects of Hormone Replacement Therapy on Urinary Deoxypyridinoline of Postmenopausal Women
|
|
유영옥
노덕영/정대영/김은중/권동진/김진홍/김대훈/김수평
|
|
|
Abstract
|
|
|
Objective :
@EN Our purpose was to determine whether the bone resorption rate is evaluated by Deoxypyridinoline(Dpd) in urine, and to evaluate the clinical utility of Dpd to monitor the hormone replacement therapy effect in postmenopausal women.
@ES Study Design :
@EN We divided the patients into three groups, the control group was the women who were postmenopausal health state, and the experimental groups were the postmenopausal hormone replacement therapy group and the podtmenopausal nontherapy group.
Urinary
Dpd and serum FSH, Osteocalcin was measured in the both groups.
@ES Results :
@EN The urinary Dpd and serum osteocalcin were significantly increase in postmenopausal group(6.63±3.09 pmol/μmol creatinine ; 10.54±3.77 ng/ml) compared to premenopausal group(4.15±1.32 pmol/μmol creatinine ; 7.85±2.17 ng/ml). The urinary
Dpd and
Serum osteocalcin were significantly decreased in the postmenopausal HRT group(3.31±1.79 pmol/μmol creatinine ; 8.31±3.13 ng/ml) compared to the postmenopausal nontherapy group (6.63±3.09 pmol/μmol creatinine; 10.54±3.77 ng/ml).
In postmenopausal nontherapy group, there was no correlation between urinary Dpd and serum osteocalcin. But these markers were good correlated in postmenopausal HRT group.
@ES Conclusion :
@EN It is concluded that the assay of urinary Dpd is useful for the resorption marker of postmenopausal osteoporosis and it should be useful for the monitoring of hormone replacement therapy effect in postmenopausal women. Furthermore, urinary
Dpd
may
be an important indicator to determine when to resume the therapy during cessation of HRT.
|
|
|
KEYWORD
|
|
|
|
|
|
FullTexts / Linksout information
|
|
 
|
|
|
Listed journal information
|
|
  
|